Friday, May 14, 2010

Genetic ancestry tests imperfect say researchers

More than 40 companies, including 23andMe Inc in Mountain View, California, in which Google has invested, and privately held Pathway Genomics Corp in San Diego, sell the tests to consumers.
They are not intended to provide insight into health information. Instead, the tests give a rough estimation of a person's genetic ancestry.
But the growing popularity of the tests, which are not regulated, has raised some concerns among genetic experts who fear consumers are not fully aware of their limitations.
"A major issue regarding commercial ancestry testing is that there is no quality assurance guarantee," according to a report led by researchers at Duke University on behalf of the American Society of Human Genetics and published in The American Journal of Human Genetics.
Joann Boughman, executive vice president of the American Society of Human Genetics, said genetic ancestry testing is very useful for understanding genetic differences in things like blood type or genetic diseases in large populations of people.
But they are less useful for individuals.
"If you swabbed your cheek and sent your DNA off to find out what your ancestral origins are, you would get a result back saying you are 5 percent African, 12 percent European and 70 percent Asian, or something like that," Boughman said.
"The question we want people to think about is, what does that mean? Why would I want that information?"
The group is concerned that consumers who get the test results might read too much into them.
"Sometimes there are social and political and even economic implications," Boughman said in a telephone interview. "In some states in the country, you have to prove you are a member of a specific Indian tribe to have access to either land or earnings from investments even in casinos.
"One of the ways you would supposedly be able to prove or disprove you were from that tribe is through this genetic ancestry testing," she said.
A negative result could mean that those genes had been lost in an individual's line because parents only pass along half of their genes to their children, she said.
Spokesmen for Pathway and 23andMe Inc could not be immediately reached for comment.
Boughman said genetic ancestry testing is different from direct-to-consumer genetic tests for health information, but the group has concerns about those too.
Walgreen Co this week planned to distribute genetic health tests from Pathway Genomics in its stores, but put those plans on hold after the U.S. Food and Drug Administration expressed concerns that the tests were not approved by the agency.Pilipaca
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Celtics send Cavaliers and LeBron James? packing

It wasn't just the East draw that trembled Thursday night, but the entire NBA balance of power as the so-recently mighty Cleveland Cavaliers fell to Earth in the last game on LeBron James' contract.
In a crowning indignity at a particularly bad time, with James about to decide his future, the Cavaliers fell Thursday night, 94-85, to the aging Boston Celtics, who captured the series they started as heavy underdogs, 4-2.
The Celtics, who staggered down the stretch, falling to No. 4 and into the Cavaliers' bracket, which seemed like a bad idea at the time, advance to the Eastern Conference finals against Orlando.
The Cavaliers advance to the off-season with a newly enhanced possibility of losing James as a free agent.
With the crowd chanting "New York Knicks!", James went out looking like the imitation of himself he'd been since his left-handed free throw at the end of the Chicago series revealed he had a sore right elbow.
"I'm not using the elbow for an excuse," said James. "It limited me some. You hope to be 100 percent going into the series but at this point of the season, I don't know anybody who's 100 percent."
Actually, James looked closer to 50 percent, given a major part of his game, driving the ball to the basked right-handed, was missing.
Being LeBron, he was still capable of getting a triple-double on a difficult night Thursday, with 27 points, 19 rebounds and 10 assists.
However, he didn't put his stamp on the game, as he always had but did only once in this series, in Game 3, and never looked like his old runaway train self.
He often played more like a point guard than the game's ultimate weapon, and often dropped out of the offense, altogether.
Thursday he took only 21 shots, missed 13 and turned the ball over nine times, putting him one from a farewell quadruple-double.
The Cavaliers reeled into town off their Game 5 debacle, in which they lost by 32 points with James shooting three for 14 in their own Quicken Loans Arena, known locally as "The Q" or not, as Cleveland Plain Dealer columnist Bill Livingston called it, "The Quit."
With owner Dan Gilbert noting the effort wasn't "anywhere near the high expectations all of us have," the Plain Dealer's Brian Windhorst compiled a list of endangered Cavaliers that read like the team directory: General Manager Danny Ferry, Coach Mike Brown, Shaquille O'Neal.
Between games, James was his light-hearted self, joking with teammates in a shooting contest, "I got a handicap sticker on."
Of course, he continued to insist to the media that nothing was wrong, even while noting matter-of-factly his elbow was still bothering him.
"You always have certain injuries you hope they don't flare up during the course of the game," he said before Game 6. "But I always feel pretty good before the game.
"With the elbow, it's just a matter of going out and seeing how it feels that day."
It didn't look like it felt that good Thursday either. The Cavaliers trailed, 51-49, at the half after twice coming back from double-digit deficits, because Mo Williams put on a LeBron-esque show, scoring 20 points.
Williams finished with 22. Without James putting them on those broad shoulders, as he has for the seven seasons that led up to the start of this series, the Cavaliers were over their heads.
"I geared myself for the postseason," said James, declining to speculate on his intentions. "The fact that it's over right now is definitely a surprise to myself but it is what it is.
"A friend of mine told me, 'I guess you have to go through a lot of nightmares before you finally accomplish your dreams.'
"And that's what's going on for me as an individual right now."Responsibilities
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